Reaction #312609

Reaction equation

1-(phenylsulfonyl)-4-piperazin-1-yl-1H-indole

benzyl bromide

triethyl-amine

→

title product

4-(4-Benzylpiperazin-1-yl)-1-(phenyl-sulfonyl)-1H-indole

Solvents

tetrahydrofuran

Conditions

Workup

1. 1
   Concentrationconcentrated in vacuo
2. 2
   Otherto give a residue
3. 3
   OtherThe residue is purified by RP-HPLC

Procedure

A solution of 1-(phenylsulfonyl)-4-piperazin-1-yl-1H-indole (71 mg, 0.18 mmol) in tetrahydrofuran is treated sequentially with benzyl bromide (21 μl) and triethyl-amine (75 μl ), shaken at room temperature for 16 hr and concentrated in vacuo to give a residue. The residue is purified by RP-HPLC to give the title product, 37 mg, identfied by HPLC and mass spectral analyses (2.81 min; 432 M+H) using the LCMS conditions described in Table I.

Source