Reaction #312606

Reaction equation

triphosgene

4-methoxy-piperidine hydrochloride salt

pyridine

→

4-Methoxy-piperidine-1-carbonyl chloride

Solvents

dichloromethane

dichloromethane

Conditions

Workup

1. 1
   Filtrationfiltered through a silica pad
2. 2
   Washeluting with dichloromethane
3. 3
   Otherevaporated
4. 4
   OtherAfter trituration with diisopropyl ether, the mixture was used without purification

Procedure

To a stirred solution of triphosgene (7.4 g, 0.025 mmol) in dichloromethane (200 ml) at ice bath was added dropwise a solution of 4-methoxy-piperidine hydrochloride salt (10 g, 0.066 mmol) and pyridine (10.9 g, 0.139 mmol) in dichloromethane (100 ml). The mixture was stirred over night and filtered through a silica pad, eluting with dichloromethane and evaporated. After trituration with diisopropyl ether, the mixture was used without purification.

Source