Reaction #309167

Reaction equation

6-chloro-2,3-pyrazinediamine

DIPEA

methyl oxo(phenyl)acetate

→

6-chloro-3-phenylpyrido[2,3-b]pyrazin-2-ol

Solvents

THF

Conditions

Workup

1. 1
   ConcentrationThe solvent was concentrated under reduced pressure, and EtOAc
2. 2
   workup.ADDITIONwas added
3. 3
   FiltrationThe resulting solid was collected by filtration

Procedure

A mixture of 6-chloro-2,3-pyrazinediamine (3-1) (15.3 g, 107 mmol), DIPEA (37.2 mL, 213 mmol), and methyl oxo(phenyl)acetate (26.2 g, 160 mmol) in THF (300 mL) was stirred at room temperature for 2 days. The solvent was concentrated under reduced pressure, and EtOAc was added. The resulting solid was collected by filtration to give 6-chloro-3-phenylpyrido[2,3-b]pyrazin-2-ol (3-2) as yellow powder.

Source