Reaction #3070

Reaction equation

aldehyde

3-iodo-4-methylbenzaldehyde

n-BuLi

→

3-iodo-4-methylstyrene

Solvents

THF

Conditions

Workup

1. 1
   Extractionprocessed by extraction and chromatography

Procedure

This aldehyde (1 mmol)was added to a premixed solution of 1.5 mmol of methyl triphenylphosphonium bromide and 1.2 mmol of n-BuLi in 5 mL of THF at 0° C. and this mixture was stirred for 3-6 h at rt and then processed by extraction and chromatography to give 3-iodo-4-methylstyrene.

Source