Reaction #3068

Reaction equation

iodine

3-iodo-4-methylbenzoic acid

NaBH4

→

3-iodo-4-methylbenzyl alcohol

Solvents

THF

THF

Conditions

Workup

1. 1
   workup.STIRRINGAfter stirring for 2 h the mixture
2. 2
   Extractionwas processed by extraction

Procedure

A mixture of 1.0 mmol of 3-iodo-4-methylbenzoic acid and 1.2 mmol of NaBH4 in 4 mL of anhydrous THF was stirred for 30 min and then 0.5 mmol of iodine in 2.0 mL of THF at 5° C. was added. After stirring for 2 h the mixture was processed by extraction to provide 3-iodo-4-methylbenzyl alcohol.

Source