Reaction #306674

Reaction equation

metformin HCl

→

Metformin

Solvents

water

Conditions

Workup

1. 1
   workup.ADDITIONslowly adding 735 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours and upon completion
3. 3
   Otherbefore decanting the supernatant
4. 4
   OtherThe wet resin complex was then dried in a VWR™ convection oven
5. 5
   workup.ADDITIONKOLLICOAT™ SR-30D (250 g) was first mixed with 150 g of purified water
6. 6
   workup.ADDITIONthe mixture was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
7. 7
   Otherto form a uniform mass
8. 8
   OtherThe wet mass was again dried in a 50° C
9. 9
   OtherThe semi-dried granules were then milled through a 40 mesh screen
10. 10
    Otherdrying
11. 11
    Othercontinued at 50° C. until the moisture content
12. 12
    OtherThe dried granules were then milled through a 40 mesh screen

Procedure

The Metformin Resin Complex was prepared by first dissolving 225 g of metformin HCl in 4 L of purified water, and then slowly adding 735 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D (250 g) was first mixed with 150 g of purified water and the mixture was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried in a 50° C. VWR™ convection oven to the moisture content about 20%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and drying continued at 50° C. until the moisture content was between 3-7%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

Source