Reaction #302890

Reaction equation

2,3-dichlorobenzylamine

2-chloroethylisothiocyanate

→

title compound

Yield 163.2%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Yield 163.2%

Solvents

1,4-dioxane

Conditions

Workup

1. 1
   Otherwas placed in a sealed reaction vial
2. 2
   Temperatureto cool
3. 3
   Othera solid precipitate that had formed
4. 4
   Filtrationwas collected by filtration
5. 5
   WashThe solid was rinsed with diethyl ether
6. 6
   Otherwas dried under reduced pressure

Procedure

A mixture of 0.5 gram (0.0028 mole) of 2,3-dichlorobenzylamine and 0.27 gram (0.0081 mole) of 2-chloroethylisothiocyanate in 10 mL of 1,4-dioxane was placed in a sealed reaction vial. The reaction mixture was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 0.68 gram of the title compound. The NMR spectrum was consistent with the proposed structure.

Source