Reaction #302887

Reaction equation

methylamine

ethyl 2-(2-methoxymethyl-phenyl)-2-oxoacetate

( 1 )

ethyl 2-(2-methoxymethyl-phenyl)-2-oxoacetate

methanol

→

2-(2-methoxymethyl-phenyl)-N-methyl-2-oxo-acetamide

Solvents

water

toluene

toluene

Conditions

Workup

1. 1
   workup.ADDITIONwere mixed
2. 2
   Otherwhile retaining at 25° C.
3. 3
   Otheran organic layer was recovered
4. 4
   WashThe organic layer was washed with 178 g of 5% hydrochloric acid, 54.4 g of an aqueous saturated sodium bicarbonate solution, and 54.4 g of water
5. 5
   Concentrationrespectively, and concentrated with an evaporator

Procedure

28.3 g of the ethyl 2-(2-methoxymethyl-phenyl)-2-oxoacetate obtained in (1), 109 g of toluene, and 54.4 g of methanol were mixed, 28.6 g of a 40% aqueous methylamine solution was added while retaining at 25° C., and the mixture was retained at 25° C. for 2 hours. Thereafter, 54.4 g of water was added, 80 g of toluene were further added, this was allowed to stand still, and an organic layer was recovered. The organic layer was washed with 178 g of 5% hydrochloric acid, 54.4 g of an aqueous saturated sodium bicarbonate solution, and 54.4 g of water, respectively, and concentrated with an evaporator to obtain 12.0 g of 2-(2-methoxymethyl-phenyl)-N-methyl-2-oxo-acetamide.

Source