Reaction #302882

Reaction equation

1,5-Dichloroanthraquinone

3-amino-1-propanol

water

→

1,5-Bis(3-hydroxypropylamino)-anthraquinone

Solvents

DMSO

Conditions

Workup

1. 1
   TemperatureThe mixture is cooled to ˜80°
2. 2
   Otherhas reached RT
3. 3
   Otheris isolated by filtration
4. 4
   Washwashed with water (2×50 mL)
5. 5
   Otherthe un-dissolved product is isolated by filtration
6. 6
   Otherdried

Procedure

1,5-Dichloroanthraquinone (2.8 g; 10 mmol) is mixed with 3-amino-1-propanol (10 mL) in DMSO (50 mL) and heated to 130° C. for 4 hours. The mixture is cooled to ˜80° and added water (150 mL). When the mixture has reached RT the formed precipitate is isolated by filtration, washed with water (2×50 mL), boiled in toluene (200 mL) and the un-dissolved product is isolated by filtration and dried. Yield: 3.2 g (90%).

Source