Reaction #3013

Reaction equation

2,6-dimethoxy-4-methylaniline

cyclohexanone

water

→

N-cyclohexylidene-2,6-dimethoxy-4-methylaniline

Solvents

toluene

Conditions

Workup

1. 1
   Temperaturethe reaction mixture is heated
2. 2
   Temperatureat reflux for 18 hours
3. 3
   Otheris removed as it
4. 4
   Otheris formed in the reaction mixture
5. 5
   OtherThe toluene is evaporated

Procedure

4.2 g of 2,6-dimethoxy-4-methylaniline are dissolved in 50 ml of toluene, 2.45 g of cyclohexanone are then added and the reaction mixture is heated at reflux for 18 hours. The water which is formed is removed as it is formed in the reaction mixture using a Dean and Stark apparatus. The toluene is evaporated and the oily N-cyclohexylidene-2,6-dimethoxy-4-methylaniline residue obtained is used without addition of purification in the following stage.

Source