Reaction #2823

Reaction equation

Morpholine

3-nitro-4-valeramidobenzoic acid

Dicyclohexylcarbodiimide

1-hydroxybenzotriazole

→

3-nitro-4-valeramidobenzoic acid morpholide

Solvents

tetrahydrofuran

Conditions

Workup

1. 1
   workup.STIRRINGThe mixture was stirred for 16 hours
2. 2
   OtherAfter the insolubles were removed from the reaction solution
3. 3
   Concentrationthe solution was concentrated
4. 4
   Otherdried
5. 5
   workup.DISSOLUTIONThe crude product was dissolved in chloroform
6. 6
   Otherthe insolubles were removed
7. 7
   Otherthe solution was purified by silica gel column chromatography (Kieselgel 60=400 g, chloroform/methanol=30/1)
8. 8
   Otherto obtain the compound ([1]-(12)-1) (22.95 g) as yellow needle crystals

Procedure

In tetrahydrofuran (800 ml), 3-nitro-4-valeramidobenzoic acid ([1]-(11)-1) (20.0 g) was dissolved. Dicyclohexylcarbodiimide (17.1 g) and 1-hydroxybenzotriazole (11.2 g) were added to the solution, and the mixture was stirred at room temperature for 15 minutes. Morpholine (7.27 g) was further added to the solution. The mixture was stirred for 16 hours. After the insolubles were removed from the reaction solution, the solution was concentrated and dried. The crude product was dissolved in chloroform, and the insolubles were removed, and the solution was purified by silica gel column chromatography (Kieselgel 60=400 g, chloroform/methanol=30/1) to obtain the compound ([1]-(12)-1) (22.95 g) as yellow needle crystals.

Source