Reaction #2767

Reaction equation

trifluoroacetic acid ethyl ester

1,4,7-triazaheptane

→

1,7-Bis(trifluoroacetyl)-1,4,7-triazaheptane

Solvents

tetrahydrofuran

Conditions

Workup

1. 1
   Concentrationconcentrated by evaporation in a vacuum
2. 2
   OtherThe remaining oil is crystallized from hexane

Procedure

113.3 g (790 mmol) of trifluoroacetic acid ethyl ester is instilled in a solution of 41.14 g (390 mmol) of 1,4,7-triazaheptane in 350 ml of tetrahydrofuran at 0° C. and under nitrogen. It is allowed to stir overnight at room temperature, concentrated by evaporation in a vacuum. The remaining oil is crystallized from hexane.

Source