Reaction #2744

ord-88bba747b04c4ea0a87b10994af1c1f6

Reaction equation

CC[C@H](C)CBr
(S)-1-bromo-2-methylbutane
CCCCC[Si]1(c2ccccc2)CCC(c2cc(F)c(OS(=O)(=O)C(F)(F)F)c(F)c2)CC1
(2,6-difluoro-4-(4-n-pentyl-4-phenyl-4-silacyclohexyl)phenyl) trifluoromethanesulfonate
→
CCCCC[Si@H]1CC[C@H](c2cc(F)c(C[C@@H](C)CC)c(F)c2)CC1
(S)-4-(trans-4-n-pentyl-4-silacyclohexyl)-1-(2-methylbutyl)-2,6-difluorobenzene

Reactants

CC[C@H](C)CBr
(S)-1-bromo-2-methylbutane
CCCCC[Si]1(c2ccccc2)CCC(c2cc(F)c(OS(=O)(=O)C(F)(F)F)c(F)c2)CC1
(2,6-difluoro-4-(4-n-pentyl-4-phenyl-4-silacyclohexyl)phenyl) trifluoromethanesulfonate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherobtaining the intended compound

Procedure

The general procedure of Example 18 was repeated using (S)-1-bromo-2-methylbutane and (2,6-difluoro-4-(4-n-pentyl-4-phenyl-4-silacyclohexyl)phenyl) trifluoromethanesulfonate, thereby obtaining the intended compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05730902uspto-grants-1998_03