Reaction #2602

ord-9cec41e879094d138e4a40b6eea1b5f3

Reaction equation

COc1cccc(N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)C(=O)c2ccc(N)cc2)c1
4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide
CS(=O)(=O)Cl
methanesulfonyl chloride
COc1cccc(N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)C(=O)c2ccc(NS(C)(=O)=O)cc2)c1
title compound
Yield 95.4%
COc1cccc(N(CCN2CCC(C(=O)c3ccc(F)cc3)CC2)C(=O)c2ccc(NS(C)(=O)=O)cc2)c1
N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-methanesulfonylamino-N-(3-methoxyphenyl)benzamide
Yield 95.4%

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Using 4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide (475.0mg, 1.00 mmol) and methanesulfonyl chloride (0.12 ml, 1.50 mmol), the procedure of inventive Example 94 was repeated to obtain 527.8 mg (95.4%) of the title compound in a colorless amorphous form.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728835uspto-grants-1998_03