Reaction #2510562

ord-e927ec18400f4fb68541b3cfdd6578e9

Reaction equation

C=C(C)[C@@H]1CC[C@@H](C)C[C@H]1O
L-isopulegol
[H][H]
hydrogen
→
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
L-menthol

Reactants

C=C(C)[C@@H]1CC[C@@H](C)C[C@H]1O
L-isopulegol
[H][H]
hydrogen

Reagents

None

Conditions

Temperature
80°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherto 75° C

Procedure

Example 1 was repeated using L-isopulegol with a purity of 99.9% by weight and 99.8% ee, which was introduced at a rate of 12.6 g/h (total amount 303 g) into the reactor at a hydrogen pressure of 40 bar. The main reactor (MR) was heated to 80° C., the postreactor to 75° C. L-menthol (99.8% ee) was obtained in an amount of 306 g corresponding to a rate of 12.8 g/h. The chemical purity of the L-menthol output is compiled in Table 2.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07960593B2uspto-grants-2011_06