Reaction #2507842

Reaction equation

toluene

2,5-difluoro-4-(2-propynyloxy)benzoic acid

thionyl chloride

→

2,5-difluoro-4-(2-propynyloxy)benzoyl chloride

Solvents

DMF

Conditions

Workup

1. 1
   Temperaturethe mixture was heated
2. 2
   Temperatureto reflux for 2 hours
3. 3
   ConcentrationThen, the reaction mixture was concentrated under reduced pressure

Procedure

To 20 ml of toluene were added 1.4 g of 2,5-difluoro-4-(2-propynyloxy)benzoic acid, 0.8 ml of thionyl chloride and 10 mg of DMF, and the mixture was heated to reflux for 2 hours. Then, the reaction mixture was concentrated under reduced pressure, and 1.5 g of 2,5-difluoro-4-(2-propynyloxy)benzoyl chloride was obtained.

Source