Reaction #2507831

Reaction equation

7-bromomethyl-6-fluoro-3-pentylchroman

triphenylphosphine

→

(6-Fluoro-3-pentylchroman-7-ylmethyl)triphenylphosphonium bromide

Solvents

acetonitrile

Conditions

Workup

1. 1
   TemperatureThe batch is subsequently cooled to 0° C.
2. 2
   Filtrationthe precipitated (6-fluoro-3-pentylchroman-7-ylmethyl)triphenylphosphonium bromide is filtered off with suction
3. 3
   Otherdried in vacuo

Procedure

11.0 g (34.9 mmol) of 7-bromomethyl-6-fluoro-3-pentylchroman and 9.20 g (35.1 mmol) of triphenylphosphine are dissolved in 70 ml of acetonitrile, and the mixture is stirred overnight at room temp. The batch is subsequently cooled to 0° C., and the precipitated (6-fluoro-3-pentylchroman-7-ylmethyl)triphenylphosphonium bromide is filtered off with suction and dried in vacuo.

Source