Reaction #2487439

Reaction equation

2-fluoro-3-methylbenzonitrile

NBS

AIBN

→

crude material

3-(Bromomethyl)-2-fluorobenzonitrile

Solvents

1,2-dichloroethane

Conditions

Workup

1. 1
   OtherAfter complete consumption of the starting material (by TLC)
2. 2
   Temperaturethe reaction mixture was cooled to RT
3. 3
   OtherThe volatiles were removed under reduced pressure

Procedure

To a stirred solution of 2-fluoro-3-methylbenzonitrile (200 mg, 1.5 mmol) in 1,2-dichloroethane (30 ml) was added NBS (266 mg, 1.49 mmol) and AIBN (29 mg, 0.15 mmol) at RT. The reaction mixture was then heated to 80° C., and the reaction mixture was stirred for 2 h. After complete consumption of the starting material (by TLC), the reaction mixture was cooled to RT. The volatiles were removed under reduced pressure to obtain the crude material. Purification by silica gel column chromatography eluting with 2-3% EtOAc/hexane afforded compound I-6 (250 mg, 1.15 mmol, 78%) as colorless liquid. 1H NMR (500 MHz, CDCl3): δ 7.69-7.65 (m, 1H), 7.62-7.58 (m, 1H), 7.28-7.25 (m, 1H), 4.50 (s, 2H).

Source