Reaction #2467985

Reaction equation

Methyl 4-aminothiophene-3-carboxylate hydrochloride

ammonia

→

oil

Yield 65.0%

Methyl 4-aminothiophene-3-carboxylate

Yield 65.0%

Solvents

water

Conditions

Workup

1. 1
   ExtractionThe solution was extracted with chloroform
2. 2
   Washthe combined chloroform layer was washed with water, brine
3. 3
   Dryingdried over sodium sulfate
4. 4
   FiltrationThe solution was filtered
5. 5
   Otherevaporated the solvent

Procedure

Methyl 4-aminothiophene-3-carboxylate hydrochloride (290 mg) was dissolved in water (20 mL) and basified with ammonia solution. The solution was extracted with chloroform and the combined chloroform layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the product as pale yellow color oil (150 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.92 (1H, d, J=3.6 Hz), 6.08 (1H, d, J=3.6 Hz), 4.79 (2H, br s), 3.85 (3H, s).

Source