Reaction #2467945

Reaction equation

2-Oxo-3-phenyl-propionic acid

(4-Phenyl-thiazol-2-yl)-methylamine

NaBH3CN

→

product

Yield 62.1%

3-Phenyl-2-[(4-phenyl-thiazol-2-ylmethyl)-amino]-propionic acid

Yield 62.1%

Solvents

MeOH

Conditions

Workup

1. 1
   OtherThe product was purified by HPLC

Procedure

To a solution of 2-Oxo-3-phenyl-propionic acid (1.6 mmol, 264 mg) and (4-Phenyl-thiazol-2-yl)-methylamine (1.0 mmol, 190 mg) in MeOH (4 mL), is added NaBH3CN (2.0 mmol, 1N in THF). The pH was then adjusted at 6 with 1M HClaq. The mixture was stirred at room temperature for 3 days. The product was purified by HPLC to give the pure product (210 mg, 62%).

Source