Reaction #2467939

Reaction equation

2-Chloro-5-phenyl-[1,3,4]thiadiazole

hydrazine hydrate

→

2-phenyl-5-hydrazino-1,3,4-thiadiazole

Solvents

iPrOH

Conditions

Workup

1. 1
   Temperatureat reflux overnight
2. 2
   OtherThe solvent was evaporated
3. 3
   workup.ADDITIONwater was added
4. 4
   Otherthe product was isolated by filtration (110 mg, 57%)

Procedure

A solution of the 2-Chloro-5-phenyl-[1,3,4]thiadiazole (2 mmol) and hydrazine hydrate (6 mmol, 3 eq) in iPrOH (10 mL) was heated at reflux overnight. The solvent was evaporated, water was added, and the product was isolated by filtration (110 mg, 57%).

Source