Reaction #2467936

Reaction equation

thiosemicarbazide

3,4-dichlorophenylacetyl bromide

→

4-(3,4-Dichloro-phenyl)-thiazol-2-yl-hydrazine

Solvents

dioxane

Conditions

Workup

1. 1
   FiltrationThe precipitate of hydrobromide salt was filtered
2. 2
   Washwashed with dioxane (3×10 mL)
3. 3
   FiltrationThe product was filtered
4. 4
   Washwashed with water
5. 5
   Otherdried (2.08 g, 80%)
6. 6
   OtherThe product was generally satisfactory for further reaction

Procedure

A solution of a thiosemicarbazide (10 mmol, 0.91 g) and 3,4-dichlorophenylacetyl bromide (10 mmol, 2.68 g) in dioxane (20 mL) was stirred at room temperature for 16 h. The precipitate of hydrobromide salt was filtered and washed with dioxane (3×10 mL), then basified with 2N Na2CO3 (20 mL). The product was filtered, washed with water and dried (2.08 g, 80%). The product was generally satisfactory for further reaction.

Source