Reaction #2460339

Reaction equation

olanzapine

methane sulfonic acid

→

Olanzapine Mesylate

Solvents

acetone

acetone

Conditions

Workup

1. 1
   Otherovernight
2. 2
   Otherat 4° C
3. 3
   OtherCrystals were isolated by filtration
4. 4
   Washwashed with 10 ml of acetone and 20 ml of ether
5. 5
   Otherdried overnight at 40° C. in vacuo

Procedure

To a solution of 5.0 g of olanzapine base in 150 ml acetone was slowly added a solution of 1.53 g of methane sulfonic acid in 50 ml of acetone at room temperature. The mixture was stirred for 1 hour and then overnight at 4° C. Crystals were isolated by filtration, washed with 10 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 6.62 g (95%) as a hemi-acetonate.

Source