Reaction #2460337

Reaction equation

olanzapine

benzenesulfonic acid monohydrate

→

Olanzapine Besylate

Solvents

acetone

acetone

Conditions

Workup

1. 1
   workup.STIRRINGThe mixture was stirred 1 hour at room temperature
2. 2
   Otherat 4° C.
3. 3
   Otherovernight
4. 4
   OtherCrystals were isolated by filtration
5. 5
   Washwashed with 20 ml of acetone and 20 ml of ether
6. 6
   Otherdried at 40° C. under vacuum overnight

Procedure

To a solution of 5.0 g of olanzapine in 150 ml acetone was slowly added a solution of 2.8 g benzenesulfonic acid monohydrate in 50 ml acetone at room temperature under stirring. The mixture was stirred 1 hour at room temperature and then at 4° C. overnight. Crystals were isolated by filtration, washed with 20 ml of acetone and 20 ml of ether and dried at 40° C. under vacuum overnight. Yield: 5.98 g (79%).

Source