Reaction #2460334

ord-3cf0d304f55b4082ad7110d1f49aefa1

Reaction equation

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
O=C(O)CO
glycolic acid
→
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1.O=C([O-])CO
Olanzapine Glycolate

Reactants

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
O=C(O)CO
glycolic acid

Reagents

None

Solvents

CC(C)=O
acetone
CC(C)=O
acetone

Conditions

Temperature
4°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe crystals were isolated by filtration
  2. 2
    Washwashed with 15 ml of acetone and 20 ml of ether
  3. 3
    Otherdried overnight at 40° C. in vacuo

Procedure

To a solution of 5.0 g of olanzapine in 150 ml of acetone was added 1.22 g of glycolic acid in 25 ml acetone slowly at room temperature. The mixture was stirred overnight at 4° C. The crystals were isolated by filtration, washed with 15 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 5.76 g

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07459449B2uspto-grants-2008_12