Reaction #2460333

ord-061c37941fa74cd89611d45c26e6b4de

Reaction equation

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
C[C@H](O)C(=O)O
L-(+)-lactic acid
→
CC(O)C(=O)[O-].Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
Olanzapine Lactate

Reactants

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
C[C@H](O)C(=O)O
L-(+)-lactic acid

Reagents

None

Solvents

CC(C)=O
acetone
CC(C)=O
acetone

Conditions

Temperature
-20°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherthe solid was isolated

Procedure

To a clear solution of 5.0 g of olanzapine base in 150 ml acetone was added, at room temperature, a solution of 1.44 g of L-(+)-lactic acid in 50 ml of acetone. The reaction mixture was stirred at −20° C. and the solid was isolated. Yield: 3.36 g (52%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07459449B2uspto-grants-2008_12