Reaction #2460330

ord-f9089c0ec7764793ac0959d00aa29b2d

Reaction equation

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
O=C(O)c1ccccc1
benzoic acid
→
Cc1cc2c(s1)=Nc1ccccc1NC=2N1CCN(C)CC1.O=C(O)c1ccccc1
Olanzapine Benzoate

Reactants

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
O=C(O)c1ccccc1
benzoic acid

Reagents

None

Solvents

CC(C)=O
acetone
CC(C)=O
acetone

Conditions

Temperature
4°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherthe crystals were isolated by filtration
  2. 2
    Washwashed with acetone (20 ml)
  3. 3
    Otherdried overnight at 40° C

Procedure

To a clear solution of olanzapine free base (5.0 g) in acetone (150 ml) was added slowly a solution of 1.0 equivalent of benzoic acid (1.96 g) in acetone (20 ml) at room temperature. After stirring at 4° C. overnight, the crystals were isolated by filtration, washed with acetone (20 ml) and dried overnight at 40° C. Yield: 6.23 g (90%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07459449B2uspto-grants-2008_12