Reaction #2460319

Reaction equation

α,α′-dichloro-p-xylene

triethyl phosphite

→

tetraethyl p-xylylenebisphosphonate

Solvents

Conditions

Workup

1. 1
   Otherwhite crystals were formed immediately
2. 2
   TemperatureThen the mixture was cooled at 0° C.
3. 3
   Otherthe product was collected
4. 4
   Washwashed three times with 40 ml of hexanes
5. 5
   Otherisolated in 94.4% (40.8 g)
6. 6
   Otheryield

Procedure

A mixture of α,α′-dichloro-p-xylene (20 g, 0.114 mol) and triethyl phosphite (60 ml) was refluxed at 180° C. overnight. 80 ml of hexanes was added, and white crystals were formed immediately. Then the mixture was cooled at 0° C., and the product was collected, washed three times with 40 ml of hexanes and isolated in 94.4% (40.8 g) yield.

Source