Reaction #244

ord-7c9ead47a3324fac997f2b8af6afca02

Reaction equation

O=C(O)c1cc(Cl)nc(Cl)c1
O=C(O)c1cc(Cl)nc(Cl)
CC(C)(C)OC(N)=O
CC(C)(C)OC(N)=O
→
CC(C)(C)OC(=O)Nc1cc(C(=O)O)cc(Cl)n1
CC(C)(C)OC(=O)Nc1cc(

Reactants

O=C(O)c1cc(Cl)nc(Cl)c1
O=C(O)c1cc(Cl)nc(Cl)c1
CC(C)(C)OC(N)=O
CC(C)(C)OC(N)=O

Reagents

O=P([O-])([O-])[O-].[K+].[K+].[K+]
O=P([O-])([O-])[O-].[K+].[K+].
CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21
CC1(C)c2cccc(P(c3ccccc3)c3cccc
O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]
O=C(/C=C/c1ccccc1)/C=C/c1ccccc

Solvents

C1COCCO1
C1COCCO1

Conditions

Temperature
100°CELSIUS

Procedure

Reagents were mixed in a 25 mL round bottom flask and flushed well with nitrogen - heated at 100 °C for 16 h. The mixture looked dark black. Could not detect any starting material or product! It was discarded.

Source

750 AstraZeneca ELN dataset