Reaction #2358540

Reaction equation

propyl acetate

methyl acetate

dichloromethane isopropylacetate

acetate

acetate

acetate

isopropyl acetate

methanol isopropyl acetate

acetate

→

tetrahydrofuran isopropyl acetate

Solvents

dichloromethane

tetrahydrofuran

ethyl acetate

ether

ether

methanol

ethanol

Conditions

Workup

1. 1
   OtherCompounds of formula I in free form and in single stereoisomeric form thus obtained may
2. 2
   workup.ADDITIONbe converted into a salt by addition of an acid to the free base of a compound of formula I
3. 3
   workup.DISSOLUTIONE.g. a compound of formula I may be dissolved
4. 4
   Otheris obtained
5. 5
   workup.DISSOLUTIONin dissolved

Procedure

Compounds of formula I in free form and in single stereoisomeric form thus obtained may be converted into a salt by addition of an acid to the free base of a compound of formula I. E.g. a compound of formula I may be dissolved or suspended, or is obtained in dissolved or suspended form, in organic solvent, preferably a solvent or solvent mixture, such as an alcohol, e.g. methanol, ethanol; a halogenated hydrocarbon, e.g. dichloromethane; an ether, e.g. tetrahydrofuran, an acetate, such as methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate; a solvent mixture of alcohol with acetate, such as methanol/isopropyl acetate, a solvent mixture of halogenated hydrocarbon with acetate, such as dichloromethane/isopropylacetate, a solvent mixture of ether with acetate, such as tetrahydrofuran/isopropyl acetate, and to the mixture obtained an acid, e.g. an organic acid or an inorganic (mineral) acid, e.g. acetic acid, lactic acid, e.g. L-lactic acid, maleic acid, is added. A compound of formula I, in the form of a salt, e.g. crystalline salt, may be obtained and may be isolated.

Source