Reaction #2358505

ord-86231e5925954f78a659095389894bad

Reaction equation

CC(C)C(N)C(=O)O
DL-valine
C[C@H](NC(=O)c1ccccc1)C(=O)O
N-benzoyl-L-alanine
→
CC(C)[C@H](N)C(=O)O.C[C@H](NC(=O)c1ccccc1)C(=O)O
L-valine N-benzoyl-L-alanine
Yield 86.4%

Reactants

CC(C)C(N)C(=O)O
DL-valine
C[C@H](NC(=O)c1ccccc1)C(=O)O
N-benzoyl-L-alanine

Reagents

None

Solvents

O
water

Conditions

Temperature
95°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherto form a clear solution, which
  2. 2
    Temperaturewas cooled slowly
  3. 3
    TemperatureWhen the solution was cooled to room temperature after 2 hours
  4. 4
    Otherthe precipitated crystals were separated by filtration
  5. 5
    Washwashed with 50 mL of deionized water
  6. 6
    Otherdried

Procedure

Twenty four grams of DL-valine and 19.3 g of N-benzoyl-L-alanine were suspended in 200 mL of deionized water. The suspension was heated to 95° C. to form a clear solution, which was cooled slowly. When the solution was cooled to room temperature after 2 hours, the precipitated crystals were separated by filtration, washed with 50 mL of deionized water, and dried to obtain 26.8 g of crystalline L-valine N-benzoyl-L-alanine complex (L-valine to N-benzoyl-L-alanine molar ratio of 1:1).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09120722B1uspto-grants-2015_09