Reaction #2355

ord-e82a49eb230f455cbaf06730dd7d2f50

Reaction equation

CC(O)CO
propylene glycol
→
C[C@@H]1OC(=O)[C@H](C)OC1=O.O=C1CCCCCO1
ε-CAPROLACTONE L-LACTIDE

Reactants

CC(O)CO
propylene glycol

Reagents

None

Solvents

OC(C(F)(F)F)C(F)(F)F
HFIP

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherat 25° C.

Procedure

The procedure in Example 3 was substantially repeated, except that 4.4 mL (60 mmol) propylene glycol (USP grade) was used instead of 5.6 mL of 1-dodecanol. The copolymer had an inherent viscosity of 0.17 dL/g in HFIP at 25° C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05728752uspto-grants-1998_03