Reaction #2354

Reaction equation

1-dodecanol

stannous octoate

→

ε-CAPROLACTONE L-LACTIDE

Conditions

Workup

1. 1
   OtherThe copolymer was dried under vacuum (0.1mm Hg) at 110° C. for about 16 hours
2. 2
   Otherto remove any unreacted monomer
3. 3
   Otherat 25° C
4. 4
   Otherat room temperature

Procedure

The procedure in Example 1 was substantially repeated, except that 13.6 mL of 1-dodecanol instead of 4.00 mL of glycerol and 0.12 mL (40 μmol) instead of 0.10 mL of stannous octoate solution were used. The copolymer was dried under vacuum (0.1mm Hg) at 110° C. for about 16 hours to remove any unreacted monomer. The copolymer had an inherent viscosity of 0.15 dL/g in HFIP at 25° C. The copolymer was viscous liquid at room temperature. The molar ratio of PC.L/PLA was found to be 51.5/48.5 by proton NMR.

Source