Reaction #2348099

Reaction equation

hydrogen

compound ( 20 )

2-(2-(4-(4-propylphenyl)phenyl)ethenyl)-2,3-difluoro-4-ethoxytoluene

→

2-(2-(4-(4-propylphenyl)phenyl) ethyl)-2,3-difluoro-4-ethoxytoluene

Yield 81.9%

Solvents

toluene

Conditions

Workup

1. 1
   Otherwas not absorbed
2. 2
   OtherPd/C was removed by filtration
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   OtherThe residue was purified by silica gel column chromatography and recrystallization

Procedure

0.36 g of Pd/C was added to 7.29 g of the compound (20) having been dissolved in 100 mL of toluene and 100 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed by filtration, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 6.00 g of 2-(2-(4-(4-propylphenyl)phenyl) ethyl)-2,3-difluoro-4-ethoxytoluene (Compound 1-3-3-22) as colorless crystals.

Source