Reaction #2348095

Reaction equation

hydrogen

compound 1-3-3-9

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethene

→

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane

Yield 80.7%

Solvents

toluene

Conditions

Workup

1. 1
   Otherwas not absorbed
2. 2
   OtherPd/C was removed
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   OtherThe residue was purified by silica gel column chromatography and recrystallization

Procedure

0.31 g of Pd/C was added to 6.20 g of the compound 1-3-3-9 having been dissolved in 50 mL of toluene and 50 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 5.03 g of 1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane (Compound 1-3-3-1) as colorless crystals.

Source