Reaction #2329085

Reaction equation

Water

Piperidine

potassium carbonate

3-chlor-1-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]propan-1-one

→

title compound

Yield 41.7%

1-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]-3-piperidinopropan-1-one

Yield 41.7%

Solvents

N,N-dimethylformamide

Conditions

Workup

1. 1
   Extractionthe mixture was extracted with ethyl acetate
2. 2
   WashThe organic layer was washed with saturated brine
3. 3
   Dryingdried over anhydrous sodium sulfate
4. 4
   OtherThe residue obtained by evaporation of the solvent under reduced pressure
5. 5
   Otherwas purified by column chromatography on silica gel (n-hexane:ethyl acetate=1:2)

Procedure

Piperidine (0.081 g, 0.950 mmol) and potassium carbonate (0.380 g, 2.77 mmol) were added to a solution of 3-chlor-1-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]propan-1-one (compound of Reference Example 58; 0.250 g, 0.790 mmol) in anhydrous N,N-dimethylformamide (6 ml), and the mixture was stirred at room temperature for 10 hours. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The residue obtained by evaporation of the solvent under reduced pressure was purified by column chromatography on silica gel (n-hexane:ethyl acetate=1:2) to give the title compound (0.120 g, 41%) as a yellow solid.

Source