Reaction #2329083

Reaction equation

Bromoacetone

potassium carbonate

1-(2-fluoro-4-nitrophenyl)piperazine

→

title compound

Yield 83.0%

1-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]propan-2-one

Yield 83.0%

Solvents

acetone

Conditions

Workup

1. 1
   OtherThe residue obtained by evaporation of the solvent under reduced pressure
2. 2
   Washwas washed with water

Procedure

Bromoacetone (0.336 ml, 4.00 mmol) and potassium carbonate (1.38 g, 10.00 mmol) were added to a solution of 1-(2-fluoro-4-nitrophenyl)piperazine (compound of Reference Example 52; 0.390 g, 2.00 mmol) in acetone (10 ml) under ice cooling, and the mixture was stirred at room temperature for 18 hours. The residue obtained by evaporation of the solvent under reduced pressure was washed with water to give the title compound (0.467 g, 83%) as a yellow solid.

Source