Reaction #2329079

Reaction equation

1-fluoro-4-nitro-2-(trifluoromethyl)benzene

morpholine

diisopropylethylamine

acetonitrile

→

title compound

Yield 91.0%

4-[4-nitro-2-(trifluoromethyl)phenyl]morpholine

Yield 91.0%

Solvents

Water

Conditions

Workup

1. 1
   Temperaturewas refluxed for 8 hours
2. 2
   Otherobtained by evaporation of the solvent under reduced pressure
3. 3
   FiltrationThe precipitated crystal was collected by filtration

Procedure

A mixture of 1-fluoro-4-nitro-2-(trifluoromethyl)benzene (1 g, 4.782 mmol), morpholine (0.46 ml, 5.260 mmol), diisopropylethylamine (1.25 ml, 7.173 mmol) and acetonitrile (10 ml) was refluxed for 8 hours. Water was added to the residue obtained by evaporation of the solvent under reduced pressure. The precipitated crystal was collected by filtration to give the title compound (1.2 g, 91%) as a yellow crystal.

Source