Reaction #2329063

Reaction equation

methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-5-yl)acetate

KOH

→

product

Yield 104.9%

(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1.3-thiazol-5-yl)acetic acid

Yield 104.9%

Solvents

EtOH

Conditions

Workup

1. 1
   OtherThe solvent was then removed under reduced pressure
2. 2
   workup.DISSOLUTIONthe crude product dissolved in water
3. 3
   Otherprecipitated
4. 4
   FiltrationFiltration
5. 5
   Washwashing with water (5 mL)

Procedure

To methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-5-yl)acetate (Example 2) (0.2 g, 0.55 mmol) dissolved in EtOH (5.5 mL) was added aqueous KOH (0.6 mL, 5.5 M). The reaction mixture was stirred at room temperature for 1 h. The solvent was then removed under reduced pressure and the crude product dissolved in water. The aqueous phase was acidified using conc. HCl so that the product precipitated. Filtration and washing with water (5 mL) afforded 0.2 g, 97% product. The product was used without any further purification.

Source