Reaction #2329061

Reaction equation

3-[5-(phenyl)-5-hydroxypentanoyl]-4-phenyl-oxazolidin-2-one

4-[(4-methoxyphenylimino)methyl]benzonitrile

4-(benzylideneamino)benzonitrile

5-(4-fluorophenyl)-5-hydroxy-pentanoyl-4-phenyloxazolidin-2-one

→

Compound ( 16 )

1-(4-Aminomethylphenyl)-3-[3-hydroxy-3-phenylpropyl]-4-phenylazetidin-2-one

Conditions

Procedure

Compound (16) was prepared as described in example IIIa-d, the differences being that: a) instead of 4-[(4-methoxyphenylimino)methyl]benzonitrile, 4-(benzylideneamino)benzonitrile was used, b) instead of 3-[5-(4-fluorophenyl)-5-hydroxy-pentanoyl-4-phenyloxazolidin-2-one, 3-[5-(phenyl)-5-hydroxypentanoyl]-4-phenyl-oxazolidin-2-one was used, and c) the product IIId was subjected to reduction with Raney nickel.

Source