Reaction #2329045

Reaction equation

benzoic acid chloride

(4-chloro-phthalazin-1-yl)-hydrazine

compound C1

(4-chloro-phthalazin-1-yl)-hydrazine

→

benzoic acid (4-chloro-2H-phthalazin-1-ylidene)-hydrazide

Solvents

toluene

toluene

Conditions

Workup

1. 1
   Temperatureat reflux temperature
2. 2
   Filtrationfiltered with suction
3. 3
   ConcentrationThe filtrate is concentrated under reduced pressure
4. 4
   Otherthe residue is recrystallized from N,N-dimethylformamide

Procedure

2.5 g (4-chloro-phthalazin-1-yl)-hydrazine (compound C1) are suspended in 250 ml toluene and treated with a solution of 1.7 ml benzoic acid chloride in 50 ml toluene at reflux temperature. After 2 h the reaction mixture is cooled to ambient temperature and filtered with suction. The filtrate is concentrated under reduced pressure and the residue is recrystallized from N,N-dimethylformamide to yield 1.2 g of benzoic acid (4-chloro-2H-phthalazin-1-ylidene)-hydrazide.

Source