Reaction #2329043

Reaction equation

6-chloro-3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine

compound B1

6-chloro-3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine

p-anisidine

→

title compound

Yield 81.3%

(4-Methoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine

Yield 81.3%

Solvents

ethanol

Conditions

Workup

1. 1
   Filtrationthe precipitate is filtered with suction
2. 2
   OtherThe solid is recrystallized from N,N-dimethylformamide

Procedure

5.0 g of 6-chloro-3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine (compound B1), and 20 g p-anisidine are stirred at 170° C. for 5 h. The reaction mixture is diluted with 40 ml ethanol and the precipitate is filtered with suction. The solid is recrystallized from N,N-dimethylformamide to yield 5.2 g of the title compound. M.p.: 301-304° C.

Source