Reaction #2320113

Reaction equation

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol

trifluoroacetic acid

→

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Solvents

CH2Cl2

Conditions

Workup

1. 1
   Temperaturerefluxed for 24 hours
2. 2
   OtherThe phases were separated
3. 3
   Washthe organic phase was washed with two portions of 10%-Na2CO3
4. 4
   Dryingdried (MgSO4)
5. 5
   Filtrationfiltered
6. 6
   Otherevaporated to dryness

Procedure

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol (1.5 g) was dissolved trifluoroacetic acid (35 ml) and refluxed for 24 hours and then CH2Cl2 (200 ml) was added. The phases were separated and then the organic phase was washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 1.5 g. MS m/z (relative intensity, 70 eV) 351 (M+, 27), 172 (9), 92 (11), 91 (bp), 65 (21).

Source