Reaction #2320103

ord-6e21d7069b134f098338afdb28ba1df7

Reaction equation

Fc1ccc(Br)cc1C(F)(F)F
5-bromo-2-fluorobenzotrifluoride
CCCN1[C@H](C)CNC[C@@H]1C
cis-2,6-dimethyl-1-propyl-piperazine
Cl
HCl
→
CCCN1[C@H](C)CN(c2ccc(F)c(C(F)(F)F)c2)C[C@@H]1C
cis-4-(4-Fluoro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine

Reactants

—
( 74 )
—
( 85 )
Fc1ccc(Br)cc1C(F)(F)F
5-bromo-2-fluorobenzotrifluoride
CCCN1[C@H](C)CNC[C@@H]1C
cis-2,6-dimethyl-1-propyl-piperazine
—
( 71 )
Cl
HCl

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Otherthe title compound was recovered by the procedure
  2. 2
    Otherdescribed in Preparation 9

Procedure

Beginning with 5-bromo-2-fluorobenzotrifluoride and cis-2,6-dimethyl-1-propyl-piperazine, the title compound was recovered by the procedure described in Preparation 9: m.p. 221° C. (HCl), MS m/z (rel. intensity, 70 eV)) 318 (M+, 32), 289 (74), 112 (bp), 70 (71), 56 (85).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE041315E1uspto-grants-2010_05