Reaction #2320101

Reaction equation

1-(3-Methanesulfonyl-4-methoxy-phenyl)-4-propyl-piperazine

HBr

→

2-Methanesulfonyl-4-(4-propyl-piperazin-1-yl)-phenol

HBr

Conditions

Workup

1. 1
   OtherThe excess of HBr was then evaporated
2. 2
   workup.ADDITIONabsolute ethanol added
3. 3
   Otherevaporated

Procedure

1-(3-Methanesulfonyl-4-methoxy-phenyl)-4-propyl-piperazine (30 mg) was dissolved in 48-% HBr (2 ml) and stirred at 120° C. under an Argon-atmosphere for 3 h. The excess of HBr was then evaporated and absolute ethanol added and evaporated. This procedure was repeated several times to yield an residue of 2-Methanesulfonyl-4-(4-propyl-piperazin-1-yl)-phenol×HBr. MS m/z (relative intensity, 70 eV) 298 (M+, 35), 269 (bp), 226 (15), 199 (12), 70 (62).

Source