Reaction #2320081

ord-0a0f9f0f11e44a66aa7372175e6c0475

Reaction equation

FC(F)(F)c1cc(C2CCNCC2)ccc1Cl
4-(4-Chloro-3-trifluoromethyl-phenyl)-piperidine
CCCI
1-propyliodide
→
CCCN1CCC(c2ccc(Cl)c(C(F)(F)F)c2)CC1
title compound
CCCN1CCC(c2ccc(Cl)c(C(F)(F)F)c2)CC1
4-(4-Chloro-3-trifluoromethyl-phenyl)-1-propyl-piperidine

Reactants

FC(F)(F)c1cc(C2CCNCC2)ccc1Cl
4-(4-Chloro-3-trifluoromethyl-phenyl)-piperidine
CCCI
1-propyliodide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Beginning with 4-(4-Chloro-3-trifluoromethyl-phenyl)-piperidine and 1-propyliodide, the title compound was re-covered by the procedure described in Example 2. m.p. 218-220° C. (HCl), MS m/z (rel. intensity, 70 eV) 305 (M+, 4), 278 (35), 277 (13), 276 (bp), 70 (40).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: USRE041315E1uspto-grants-2010_05