Reaction #2307967

ord-84004a01edaa4803a8018f5eaee77331

Reaction equation

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid
→
CCCCCCCCCCCCCCCCCC(=O)O.CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine Stearic Acid

Reactants

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Filtrationsieved through a 120-mesh screen
  2. 2
    Otherto obtain particles

Procedure

Equal amounts of Buprenorphine particles (prepared as described in Example 4) above) and stearic acid (prepared as described in Example 3) were blended and ground. The ground material was compressed in a 13-mm round die, with a force of 5,000 pounds for 5 minutes. Compressed tablets were ground and sieved through a 120-mesh screen followed by a 230-mesh screen to obtain particles having a size range between 63-125 microns.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07368126B2uspto-grants-2008_05