Reaction #2307966

Reaction equation

Bupivacaine hydrochloride

sodium hydroxide

→

Bupivacaine

Solvents

water

Conditions

Workup

1. 1
   Otherto precipitate the Bupivacaine base
2. 2
   FiltrationThe precipitated product was filtered
3. 3
   Washfurther washed with DI water at least three times
4. 4
   OtherThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

Procedure

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in deionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixture was adjusted to 10 to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

Source