Reaction #2298627

Reaction equation

6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine

6-(3-Thienyl)-4-chlorothieno[3,2-d]pyrimidine

hydrazine monohydrate

→

(6-(3-thienyl)thieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride

Yield 66.0%

Solvents

ethanol

Conditions

Workup

1. 1
   Temperaturewas heated
2. 2
   Temperatureat reflux for 1 hour
3. 3
   Filtrationthe solid product was collected by vacuum filtration

Procedure

A suspension of 6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine (220, 65 mg, 0.26 mmol) and hydrazine monohydrate (0.1 mL, 2.1 mmol) in ethanol (1 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (6-(3-thienyl)thieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride (48 mg, 66% yield) as a white solid.

Source