Reaction #2298622

Reaction equation

7-bromo-4-chlorothieno[3,2-d]pyrimidine

7-Bromo-4-chlorothieno[3,2-d]pyrimidine

hydrazine monohydrate

→

(7-bromothieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride

Yield 73.0%

Solvents

ethanol

Conditions

Workup

1. 1
   Temperaturewas heated
2. 2
   Temperatureat reflux for 2 hour
3. 3
   Filtrationthe solid product was collected by vacuum filtration

Procedure

A suspension of 7-bromo-4-chlorothieno[3,2-d]pyrimidine (159, 80 mg, 0.32 mmol) and hydrazine monohydrate (0.2 mL, 4.1 mmol) in ethanol (1.3 mL) was heated at reflux for 2 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (7-bromothieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride (57 mg, 73% yield) as a white solid.

Source